Lisa Irving said on some occasions, drivers were verbally abusive, or harassed her about transporting her seeing-eye dog , Bernie, within the car.
One driver allegedly cut her trip short after falsely claiming to possess received her destination.
An independent arbitrator ruled Uber’s drivers had illegally discriminated against her thanks to her condition.
It rejected Uber’s claim that the corporate itself wasn’t liable, because, it argued, its drivers had the status of contractors instead of employees.
Mrs Irving, from San Francisco , said she had worried about her safety after being stranded multiple times late in the dark thanks to being rejected by drivers.
She also alleged that cancelled rides also led to her being late for work, which contributed to her being fired from her job.
The behaviour from drivers continued despite her complaining to Uber, she said.
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A spokesman for Mrs Irving said: “Of all Americans who should be liberated by the rideshare revolution, the blind and visually impaired are among those that stand to profit the foremost .
“The bottom line is that under the Americans with Disabilities Act, a seeing-eye dog should be ready to go anywhere that a blind man can go.”
In a statement issued to media following the ruling, a spokesman for Uber said the corporate is “proud” of the assistance it offers blind passengers.
“Drivers using the Uber app are expected to serve riders with service animals and suits accessibility and other laws, and that we regularly provide education to drivers thereon responsibility.
“Our dedicated team looks into each complaint and takes appropriate action,” he added.
It is not the primary time Uber has faced a legal battle from the blind community.
In 2014, The National Federation of the Blind within the US sued the ride-sharing app over guide-dog regulations.
The case was settled in 2017 when Uber agreed to make sure its drivers knew they were legally obliged to supply service to people with guide dogs.
“I’m sorry it came to the present ,” Mrs Irving told the San Francisco Chronicle newspaper.
“I would have preferred that my civil rights be respected. But it sends a robust message that this is often not acceptable.”